Seroprevalence of anti-flagellin antibody against Burkholderia pseudomallei in Taiwan.
نویسندگان
چکیده
Yao-Shen Chen, Ssu-Ching Chen, Tsu-Rong Wu, Chih-Ming Kao and Ya-Lei Chen* Section of Infectious Disease, Kaohsiung Veterans General Hospital, Graduate Institute of Environmental Education and Department of Biotechnology, National Kaohsiung Normal University, Department of Medical Technology, Fooyin Unversity, Institute of Environmental Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan
منابع مشابه
CpG-modified plasmid DNA encoding flagellin improves immunogenicity and provides protection against Burkholderia pseudomallei infection in BALB/c mice.
The plasmid DNA encoding the fliC gene of Burkholderia pseudomallei combined with CpG oligodeoxynucleotide (ODN) was injected intramuscularly into BALB/c mice, resulting in the increased production of certain humoral antibodies and flagellin-specific spleen cell clonal expansion. CpG ODN, as an immunoadjuvant, was added to the plasmid containing the fliC gene in order to obtain ongoing expressi...
متن کاملSequence polymorphism and PCR-restriction fragment length polymorphism analysis of the flagellin gene of Burkholderia pseudomallei.
Four flagellin allelic types (I to IV) of Burkholderia pseudomallei were identified based on their sequence variation and restriction fragment length polymorphism (RFLP) analysis of the amplified flagellin gene. Flagellin allelic type I was the most predominantly (75.0%) found among the 100 clinical isolates of B. pseudomallei investigated in this study.
متن کاملHuman immune responses to Burkholderia pseudomallei characterized by protein microarray analysis.
BACKGROUND We aimed to determine the antibody and T cell responses to Burkholderia pseudomallei of humans to select candidate vaccine antigens. METHODS For antibody profiling, a protein microarray of 154 B. pseudomallei proteins was probed with plasma from 108 healthy individuals and 72 recovered patients. Blood from 20 of the healthy and 30 of the recovered individuals was also obtained for ...
متن کاملSequence- and Structure-Based Immunoreactive Epitope Discovery for Burkholderia pseudomallei Flagellin
Burkholderia pseudomallei is a Gram-negative bacterium responsible for melioidosis, a serious and often fatal infectious disease that is poorly controlled by existing treatments. Due to its inherent resistance to the major antibiotic classes and its facultative intracellular pathogenicity, an effective vaccine would be extremely desirable, along with appropriate prevention and therapeutic manag...
متن کاملBurkholderia pseudomallei infection of T cells leads to T-cell costimulation partially provided by flagellin.
Burkholderia pseudomallei is the causative agent of melioidosis. While adaptive immunity has been shown to be important for host resistance to B. pseudomallei, the direct interaction of the bacteria with adaptive immune cells such as T and B cells is not well known. To address this question, we infected Jurkat T cells, as well as human primary CD4(+) and CD8(+) T cells, with live B. pseudomalle...
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عنوان ژورنال:
- Japanese journal of infectious diseases
دوره 57 5 شماره
صفحات -
تاریخ انتشار 2004